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A meaningful share of GLP-1 weight loss can be lean mass if protein intake collapses along with appetite. Commonly cited general guidance for adults losing weight on these medications is roughly 1.2–1.6 g of protein per kg of body weight per day, alongside resistance exercise; hydration estimates commonly run ~30–35 mL per kg. These are general figures, not prescriptions.

Renal disease, pregnancy, and other conditions change these targets — individualize with a clinician or registered dietitian.