Compounded semaglutide: the whole picture, priced
Semaglutide is a GLP-1 receptor agonist — it mimics the gut hormone GLP-1, slowing gastric emptying and reducing appetite signaling. The FDA-approved brands are Ozempic® and Rybelsus® (type 2 diabetes) and Wegovy® (chronic weight management). "Compounded" semaglutide is a different thing — a pharmacy preparation that is not FDA-approved — and this page treats it that way: evidence from the brand trials, prices from 19 tracked programs with a source and date on every one, and the 2026 legal reality without the sales gloss.
Quick answer
Compounded semaglutide is a 503A pharmacy preparation of semaglutide, legally available in 2026 only on an individual prescription with a documented clinical need — it is not FDA-approved and not equivalent to Ozempic® or the other brands. Reported prices run $69–$249/month across 19 tracked programs; the lowest first-party-verified rate is $119/month (NexLife 12-month plan, flat at every dose, $0 membership — our featured partner, disclosed). Brand-trial evidence: STEP-1 reported ~14.9% mean weight loss over 68 weeks with brand semaglutide 2.4 mg. Compounded versions have not been evaluated at trial scale. Talk to a licensed clinician.
Brand vs compounded: the distinction that governs everything
The brand products went through FDA review of manufacturing, sterility, stability, and dose accuracy. A compounded preparation is made by a licensed pharmacy for your prescription and skips that review by design — which is why concentration and formulation vary between pharmacies, and why the FDA has logged dosing errors tied to those differences. That does not make every compounded program illegitimate; it makes the pharmacy behind the program the single most important fact about it, which is why we run a pharmacy disclosure index.
What the trials actually showed
In STEP-1 (NEJM, 2021), brand semaglutide 2.4 mg produced roughly 14.9% mean weight loss over 68 weeks. In the SURMOUNT-5 head-to-head (2025), brand semaglutide averaged about 13.7% versus 20.2% for brand tirzepatide — a manufacturer-funded, open-label trial of the approved products. Those numbers describe the FDA-approved products in supervised trials; no compounded semaglutide has published equivalent outcome data, and individual response varies enough that averages don't decide any single case.
What it costs — the live table
Sorted by lowest published figure; read the basis column before the price. Full state-level pages: Semaglutide by state.
| Provider | Billing basis | Provenance | |
|---|---|---|---|
| Embody | $69/mo | month-to-month promo changed intra-day live promo | Reportedrangeyourself.com · 2026-08-21 |
| bmiMD | $99/mo | 12-mo plan; ($129 month-to-month); flat at every dose | Reportedrangeyourself.com · 2026-08-21 |
| CoreAge Rx | $99/mo | month-to-month | Reportedweightlossrankings.org · 2026-08 |
| HealthRX | $99/mo | 12-mo plan; flat at every dose | Reportedrangeyourself.com · 2026-08-21 |
| Strut Health | $99/mo | month-to-month | Reportedrangeyourself.com · 2026-08-21 |
| Trimi Health | $99/mo | annual plan, billed yearly up front | Reportedrangeyourself.com · 2026-08-21 |
| NexLife featured · disclosed | $119/mo | 12-mo plan; ($139 month-to-month); calendar-month billing; flat at every dose; $0 membership stale badges flagged | First-partynexlife.us · 2026-08-24 |
| Pallas Health | $139/mo | month-to-month | Reportedweightlossrankings.org · 2026-08 |
| Yucca Health | $146/mo | 6-mo plan live promo intake-gated | Reportedrangeyourself.com · 2026-07-16 |
| Sprout Health | $149/mo | month-to-month funnel-priced | Reportedrangeyourself.com · 2026-08-21 |
| TMates | $158/mo | 12-mo plan; ($249 month-to-month) | Reportedrangeyourself.com · 2026-08-21 |
| Found | $169/mo | 12-mo plan; ($289 month-to-month) | Reportedrangeyourself.com · 2026-07-25 |
| Gala GLP-1 | $179/mo | month-to-month confirm at enrollment | Reportedrangeyourself.com · 2026-07-14 |
| Henry Meds | $179/mo | month-to-month | Reportedrangeyourself.com · 2026-08-21 |
| Luvo Health | $194/mo | 12-mo plan; ($249 per 4-week cycle) 13 four-week cycles | Reportedrangeyourself.com · 2026-08-08 |
| Care Bare Rx | $199/mo | month-to-month | Reportedrangeyourself.com · 2026-08-21 |
| Enhance MD | $212/mo | month-to-month | Reportedrangeyourself.com · 2026-07-14 |
| Direct Meds | $249/mo | month-to-month | Reportedrangeyourself.com · 2026-07-25 |
| ShedRx | $249/mo | month-to-month | Reportedrangeyourself.com · 2026-07-21 |
Cost planning across the titration ladder: the semaglutide dose & cost tool. Every figure's field-level detail is in the open dataset.
Legality in 2026, in four sentences
The FDA declared the shortages resolved (tirzepatide December 2024, semaglutide February 21, 2025), which ended shortage-era mass compounding; 503B facilities wound down by March 19, 2025. What remains is 503A patient-specific compounding with a documented clinical reason the approved products won't serve that patient. Price is not such a reason, and "personalized dosing" is the contested territory Eli Lilly and Novo Nordisk are litigating. State pharmacy boards layer their own rules on top — our state pages track what differs where.
The salt-form warning, specific to semaglutide
The FDA has warned that some compounded products use semaglutide sodium or semaglutide acetate — salt forms it considers different active ingredients from the approved drug — and has issued warning letters over marketing that presents compounded preparations as interchangeable with approved ones. One question filters most of this market: "Is your product base semaglutide, and which licensed pharmacy compounds it?" A legitimate program answers both in one email; several on our pharmacy disclosure index already publish it.
Formats: injectable first
The evidence base is subcutaneous injection. Oral drops, lozenges, and "ODT" formats are sold at confident prices with no published human absorption data for these peptides by the oral-mucosal route from any seller — the full argument is in our evidence review. Price the injectable first; make any alternative-route seller show absorption data before paying a premium.
Frequently asked questions
What is compounded semaglutide?
How much does compounded semaglutide cost in 2026?
Is compounded semaglutide legal in 2026?
Compounded semaglutide vs tirzepatide — which should I take?
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